Earning the No. 1 seed gives a team a first-round bye and home-field advantage throughout the conference playoffs — two major advantages in the chase for the Lombardi. Since 2013, six of the 13 Super Bowl winners have been the top seed in their respective conference. Through six weeks, the Chiefs and 49ers lead the oddsboard. Kansas City is looking like its old self after missing the playoffs last season, while San Francisco is also off to an undefeated start. Let’s check out the No. 1 seed odds for both the AFC and NFC at DraftKings Sportsbook as of Oct. 21. This page may contain affiliate links to legal sports betting partners. If you sign up or place a wager, FOX Sports may be compensated. Read more about Sports Betting on FOX Sports. No. 1 Seed Odds AFC Kansas City Chiefs: +240Buffalo Bills: +250New England Patriots: +700Baltimore Ravens: +700Jacksonville Jaguars: +800Denver Broncos: +850Cincinnati Bengals: +1300Pittsburgh Steelers: +5000Houston Texans: +10000Las Vegas Raiders: +12000Cleveland Browns: +18000Indianapolis Colts: +25000New York Jets: +30000Los Angeles Chargers: +60000Tennessee Titans: +80000Miami Dolphins: +100000 What to know: Last season, the Broncos earned the AFC’s No. 1 seed before falling to the Patriots in heartbreaking fashion in the AFC Championship Game. In 2023, the Ravens finished 13-4 to secure the top seed but were eliminated by Kansas City in the conference championship. Now, the Chiefs are back atop the oddsboard. After missing the playoffs last season, Kansas City has started 5-0 and moved from +780 before the season to +240 to earn the AFC’s No. 1 seed. The Chiefs have claimed the top seed four times with Patrick Mahomes as their starter (2018, 2020, 2022 and 2024), reaching the Super Bowl in each of the last three instances. Kansas City’s win over the Chargers on Sunday gave Patrick Mahomes his 100th career victory in 131 starts, tying Tom Brady as the fastest quarterback to reach the milestone. Mahomes and Andy Reid also joined Bill Belichick/Tom Brady, Tony Dungy/Peyton Manning and Bud Grant/Fran Tarkenton as the only coach-quarterback duos with at least three 5-0 starts. KC is rolling. NFC San Francisco 49ers: -140Minnesota Vikings: +330Chicago Bears: +1200Detroit Lions: +1400Seattle Seahawks: +2000Green Bay Packers: +2000Carolina Panthers: +2200Los Angeles Rams: +4000New York Giants: +8000Dallas Cowboys: +10000Atlanta Falcons: +10000Philadelphia Eagles: +15000New Orleans Saints: +20000Washington Commanders: +30000Tampa Bay Buccaneers: +50000Arizona Cardinals: +50000 What to know: The Seahawks earned the NFC’s No. 1 seed in 2025, with home-field advantage helping Seattle on its way to a Lombardi Trophy. The Rams finished with the conference’s second-best record but were the No. 5 seed after finishing second in the NFC West. In 2024, the Lions went 15-2 to claim the top seed before being upset at home in the divisional round. The Eagles and 49ers earned the No. 1 seed in 2022 and 2023, respectively, and both reached the Super Bowl before losing to the Chiefs. But through six weeks of 2026, San Francisco has taken control of the oddsboard. The 49ers 6-0 start includes wins over the Rams, Broncos and Seahawks, three teams that reached their respective conference championship games last season. Their odds have shortened from +900 before the season to -140, making them the new heavy favorites to finish atop the NFC. San Francisco has been the No. 1 seed twice under Kyle Shanahan, in 2019 and 2023, and reached the Super Bowl both times. Brock Purdy has helped fuel this year’s unbeaten start with 14 touchdown passes and just two interceptions. Meanwhile, the Rams entered the season as the +305 favorites but have slipped to +4000 after a 2-4 start and a loss to the 12.5-point underdog Cardinals at home.